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Pharmacokinetics in special populations (for renal, hepatic impairment, and age), obtained after a single dose of 80 mg fexofenadine hydrochloride, were compared to those from healthy volunteers in a separate study of similar design. Effect of Age. In older subjects ( ge; 65 years old), peak plasma levels of fexofenadine were 99 greater than those observed in younger subjects (lt;65 years old). Mean fexofenadine elimination half-lives were similar to those observed in younger subjects. Renally Impaired. In subjects with mild (creatinine clearance 41-80 mLmin) to severe (creatinine clearance 11-40 mLmin) renal impairment, peak plasma levels of fexofenadine were 87 and 111 greater, respectively, and mean elimination half-lives were 59 and 72 longer, respectively, than observed in healthy volunteers.

Assessment of workers' exposure to microorganisms when using biological degreasing stations.]