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The effect of hemodialysis on the removal of pseudoephedrine is unknown. No deaths occurred in mature mice and rats at oral doses of fexofenadine hydrochloride up to 5000 mgkg (approximately 110 and 230 times, respectively, the maximum recommended human daily oral dose of ALLEGRA-D 24 HOUR (fexofenadine hcl 180 and pseudoephendrine hcl 240) on a mgm 2 basis. ) The median oral lethal dose in newborn rats was 438 mgkg allegra masters vine compilation funny 20 times the maximum recommended human daily oral dose of ALLEGRA-D 24 HOUR (fexofenadine hcl 180 and pseudoephendrine hcl 240) on a mgm 2 basis). In dogs, no evidence of toxicity was observed at oral doses up to 2000 mgkg (approximately 300 times the maximum recommended test av 308 allegra daily oral dose of ALLEGRA-D 24 HOUR (fexofenadine hcl 180 and pseudoephendrine hcl 240) on a mgm 2 basis). The oral median lethal dose of pseudoephedrine hydrochloride in rats was 1674 mgkg (approximately 55 times the maximum recommended human daily oral dose of ALLEGRA-D 24 HOUR on a mgm 2 basis). CONTRAINDICATIONS. ALLEGRA-D 24 HOUR (fexofenadine hcl 180 and pseudoephendrine hcl 240) is contraindicated in patients with known hypersensitivity to any of its ingredients. Due to its pseudoephedrine component, ALLEGRA-D 24 HOUR (fexofenadine hcl 180 and pseudoephendrine hcl 240) is contraindicated in patients with narrow-angle glaucoma or urinary retention, and in patients receiving monoamine oxidase (MAO) inhibitor therapy or within fourteen (14) days of stopping such treatment (see DRUG INTERACTIONS section ).

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