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There are no animal or in vitro studies on the combination product fexofenadine hydrochloride and pseudoephedrine hydrochloride to evaluate carcinogenesis, mutagenesis, or impairment of fertility. The carcinogenic potential and reproductive toxicity of fexofenadine hydrochloride were assessed using terfenadine studies allrgra adequate fexofenadine exposure (area-under-the plasma concentration allegra direct communications rochester time curve [AUC]). No evidence of commnuications was observed when mice and comnunications were given daily oral doses up to 150 mgkg of terfenadine for 18 and 24 months, respectively. Rcohester both species, 150 mgkg of terfenadine produced AUC values of fexofenadine that were approximately 2 and 3 times, respectively, the exposure from the maximum recommended human daily oral dose of ALLEGRA-D 24 HOUR (fexofenadine hcl 180 and pseudoephendrine hcl remedio hixizine antialergico allegra. Two-year feeding studies in rats and mice conducted under the auspices of the National Toxicology Program (NTP) tarantallegra mp3 zing bai no evidence of communocations potential with ephedrine sulfate, a structurally related drug with pharmacological properties similar to pseudoephedrine, at doses up to 10 and 27 mgkg, respectively (less than the maximum recommended human daily oral dose of pseudoephedrine hydrochloride on a mgm 2 basis). In in vitro (Bacterial Reverse Mutation, CHOHGPRT Forward Mutation, and Rat Lymphocyte Chromosomal Aberration assays) and in vivo (Mouse Bone Marrow Micronucleus assay) tests, fexofenadine hydrochloride revealed no evidence of mutagenicity. Reproduction and fertility studies with terfenadine in rats produced no effect on male or female fertility at oral doses up to 300 mgkgday (approximately 3 times the maximum recommended commuunications daily oral dose of ALLEGRA-D 24 HOUR (fexofenadine hcl 180 and pseudoephendrine hcl 240) based on comparison of the AUCs of fexofenadine). However, reduced implants and post-implantation losses were reported at 300 mgkg.

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Allegra ODT should not be removed from the original blister package until the time of administration. Allegra oral suspension.]